Jonakayem Pharma Formulation (OPC) Pvt. Ltd.
XIPAMIDE

XIPAMIDE

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Product: XIPAMIDE
Formulary: Generic Formulary
Category: Genito Urinary System
Sub Group: DIURETICS
International Brand Name: Aquaphor,Aquaphoril
Dosages: 20 MG
Unit of Packing: Tablets
In treatment of: Treatment of Oedema

Adverse Effects: 

  • Gastrointestinal disturbances 
  • Hypo kalaemia 
  • Dizziness 
  • Carbohydrate intolerance 
  • Elevated lipid levels 
  • Hyper urecaemia 
  • Nocturia 
  • Rarely other electrolyte imbalance 
  • Ototoxicity

Contraiindication: 

  • Hyper uricaemia
  • Hyper calcaemia 
  • Renal impairment 
  • Hepatic impairment 
  • Hypersensitivity to the drug 
  • Hyper sensitivity to sulfonamides 
  • Fluid and electrolyte imbalance 
  • Addison`s disease

Special Precaution: 

  • Renal and hepatic diseases 
  • Hyper urecaemia and Gout 
  • Diabetes mellitus
  • Monitor and correct Fluid and electrolyte imbalance
  • Cirrhosis 
  • Hyper calcaemia 
  • Systemic lupus erythematosus 
  • Prostatic hypertrophy

Interaction: Cholestyramine & Colestipol: decrease absorption of Xipamide. Diazoxide: Additive action-may cause hyperglycemia, hyperuricaemia and hypotension. Digitalis: Diuretic induced hypokalaemia may precipitate digitalis toxicity. Lithium: Xipamide potentiates therapeutic and toxic effects by decreasing its renal excretion. Frusemide: Synergy leading to profound diuresis and greater than predicted electrolyte loss. Non depolarizing muscle relaxants: Diuretic induced hypokalaemia enhances efficacy. Sulfonylureas: Efficacy decreased due to Xipamaide induced glucose intolerance. Chlorpropamide: Hypokalaemia. Propantheline: Bioavailability of Xipamide increased. Metoclopramide: Bioavailability of Xipamide decreased. NSAIDs: Natriuretic effect of Xipamide decreased.

Servings: Hypertension: 20mg once daily in the morning. Increased to 40mg 0nce daily if required. Oedema: 40mg once daily. Reduced gradually; based on patient`s response up to 20mg. Maximum dose: 80mg.