Jonakayem Pharma Formulation (OPC) Pvt. Ltd.
VINBLASTINE

VINBLASTINE

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Product: VINBLASTINE
Formulary: Generic Formulary
Category: Neoplastics
Sub Group: ANTI NEOPLASTIC AGENTS
International Brand Name: Alkaban, Velban
Dosages: 10 mg/10 ml
Unit of Packing: Vial
In treatment of: Treatment of Hodgkin's and non Hodgkin's Lymphoma;Testicular,Lung,Head and Neck,Breast and Renal Carcinomas,Mycosis,Fugodies,Kaposi's Sarcoma,Histiocytosis,Choriocarcinoma,Idiopathic Thrombocytopaenic Purpura

Adverse Effects: 

  • Nausea 
  • Vomiting 
  • Lowered resistance to infection 
  • Bruising or unusual bleeding 
  • Anemia 
  • Weakness
  • Sore in mouth
  • Taste changes 
  • Diarrhea 
  • Loss of appetite 
  • Visual changes 
  • Black, tarry stools 
  • Blood in urine or in stool 
  • Cough or hoarseness 
  • Fever 
  • Chills 
  • Lower back or side pain 
  • Painful or difficult urination 
  • Pinpoint red spot on skin 
  • Slurred speech
  • Swelling on leg or lower leg 
  • Shortness of breath 
  • Pulmonary fibrosis
  • Hepatotoxicity 
  • Central and peripheral neurotoxicity 
  • Stomatitis 
  • Disorientation 
  • Lethargy 
  • Ataxia
  • Thrombocytopenia 
  • Leucopenia 
  • Bone marrow suppression 
  • Alopecia 
  • Dermatitis
  • Hypertension 
  • Hyperurecemia 
  • Cranial nerve damage 
  • Ischemic cardiac toxicity 
  • Dyspnoea 
  • Bone and tumor pain

Contraiindication: 

  • Hypersensitivity to the drug 
  • Severe bone marrow suppression 
  • Bacterial infection4.recent immunizations

Special Precaution: 

  • Hepatic impairment 
  • Bronchospasm 
  • Extravasations

Interaction: Mitomycin: Acute shortness of breath and severe bronchospasm. Phenytoin: Combination chemotherapy (including vinblastine) may reduce plasmalevels and increase seizure activity. Erythromycin: Severe myalgia, neutropenia and constipation.

Servings: Intravenous- Adult- 0.1-0.5mg/kg every 7 to 10 days or 3.7mg/metre square weekly. Children- 2.5mg/metre square as a single dose every week.