Jonakayem Pharma Formulation (OPC) Pvt. Ltd.


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Formulary: Generic Formulary
Category: Respiratory System
International Brand Name: Dimethylxanthine
Dosages: 169.4MG+50.6 MG/2ML; 115MG +35 MG; 231MG+69 MG; 346MG +104 MG; 46.5 MG +14 MG/5ML; 77MG + 23MG
Unit of Packing: inj-2ml/ Tablest/ Bottles
In treatment of: Acute Bronchospasm

Adverse Effects: 

  • Upset stomach 
  • Stomach pain
  • Diarrhea 
  • Headache 
  • Restlessness 
  • Insomnia 
  • Irritability
  • Vomiting 
  • Increased or rapid heart rate 
  • Irregular heartbeat 
  • Seizures
  • Skin rash


  • Hypersensitivity to the drug
  • Peptic ulcer 
  • Underlying seizure disorders

Special Precaution: 

  • Cardiac disease 
  • Hypertension 
  • Hyperthyroidism 
  • Hepatic impairment 
  • Fever

Interaction: Benzodiazepines: Sedative effects may be antagonized. Beta agonists: Additive effect. Halothane: Catecholamine induced arrhythmias may occur. Tetracyclines: Theophylline adverse reaction may be enhanced. Food: Theophylline elimination is increased by a low carbohydrate, high protein diet.

Servings: Adults: Long term management of chronic bronchospasm: 300 to 1000 mg daily in divided doses in every 6 to 8 hrs or 175 to 500 mg every 12 hrs for modified release preparations. Bronchospasm- Adults- 5mg/kg body weight every 6 to 8 hrs. Children- 5 mg/kg every 4 to 6 hrs. Neonatal apnoea of prematurity- Child- More than 24days - 5mg/kg as maintenance dose and 1.5mg/kg every 12 hrs as loading dose. Less than 24 days- 1mg/kg every 12 hrs. Intravenous- Management of severe bronchospasm- Adult- 4 to 5 mg/kg as loading dose over 20 to 30 minutes. 0.4 mg/kg/hr as maintenance dose. Children- 4 to 5 mg/kg as loading dose over 20 to 30 minutes. 0.8mg/kg/hr as maintenance dose.