Jonakayem Pharma Formulation (OPC) Pvt. Ltd.
TERBUTALINE

TERBUTALINE

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Product: TERBUTALINE
Formulary: Generic Formulary
Category: Respiratory System
Sub Group: ANTIASTHAMATICS
International Brand Name: Brethine, Bricanyl, Brethaire
Dosages: 2.5 MG ; 5 MG; 1.5 MG/5ML; 0.5 MG/ML; 250 MCG/1PUFF; 10 MG/ML; 5 MG; 7.5 MG
Unit of Packing: Tablets/ Capsules/ Bottles/ Inhalers
In treatment of: Acute Bronchospasm

Adverse Effects: 

  • Drowsiness 
  • Headache 
  • Dizziness 
  • Nervousness 
  • Tremor 
  • Weakness
  • Palpitations
  • Tachycardia
  • Arrhythmia 
  • Vomiting
  • Nausea
  • Heartburn 
  • Diaphoresis 
  • Dry and irritated nose (inhalation) 
  • Hypokalaemia (high dose)

Contraiindication:  Hypersensitivity to Terbutaline and other sympathomimetic amines.

Special Precaution: 

  • Myocardial insufficiency 
  • Arrhythmia 
  • Hypertension 
  • Hyperthyroidism 
  • Epilepsy 
  • Diabetes

Interaction: Other Sympathomimetic bronchodilators or epinephrine: Combined effect on the cardiovascular system may be deleterious to the patient. MAOIs and TCAs: Effect of terbutaline on vascular system may be potentiated. Beta-adrenergic blocking agents: Block the pulmonary effect of terbutaline and may produce severe asthmatic attacks in asthmatic patients. Beclomethasone, Theophylline: Synergy when used with these agents. Food: Reduces bioavailability of terbutaline.

Servings: Adult: Oral: Initial dose: 7.5 mg / day in 3 divided doses, if needed dose can be increased to 15mg /day in 3 divided doses. Subcutaneous /Intramuscular/slow IV infusion: 250 - 500mcg 3 - 4 times daily Aerosol inhalation: 250 - 500mcg every 6 - 8 hours Nebulised solution inhalation: 5 - 10 mg every 6 - 12 hours. Children: Oral: Initial dose: 2.5 mg in 2-3 times daily Subcutaneous /Intramuscular/slow IV infusion: 10mcg /kg body weight dose can be increased to 300 mcg / day Aerosol inhalation: 250 - 500mcg every 6 - 8 hours Nebulised solution inhalation: 2 - 5 mg every 6 - 12 hours. Premature labor (IV): Initial dose: 10mcg/minute and dose can be repeated until effective therapeutic response is obtained. Maximum dose: 80mcg/minute. Maintenance dose (IV dosage): Minimum effective dose for 4 hours.