Jonakayem Pharma Formulation (OPC) Pvt. Ltd.


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Formulary: Generic Formulary
Category: Genito Urinary System
International Brand Name: Aldactone, Novo-Spiroton,Aldactaczide, Spiractin,Spirolone, Berlactone
Dosages: 25 mg/100 mg
Unit of Packing: Tablets
Adverse Effects: 
  • Headache
  • Drowsiness
  • Nausea
  • Duodenal and gastric bleeding
  • Ulceration
  • Gynecomastia
  • Menstrual irregularities
  • Testicular atrophy
  • Ataxia
  • Impotence
  • Diarrhoea
  • Vomiting
  • Hyper kalemia
  • Hyponatraemia
  • Agranulocytosis
  • Altered levels of blood urea nitrogen
  • Gastro intestinal disturbances
  • Rashes
  • Ototoxicity


  • Hypersensitivity to the drug
  • Hyper kalaemia
  • Anuria
  • Acute and progressive renal insufficiency

Special Precaution: 

  • Renal impairment
  • Hepatic impairment
  • Fluid and electrolyte imbalance

Interaction: ACE Inhibitors: Enhanced hypotensive effect; significant hyperkalaemia may occur. Digitalis glycosides: Interaction is complex and may result in increased serum digoxin levels & subsequent digitalis toxicity. Cyclosporin: Increased risk of hyperkalaemia. Potassium Preparations: May result in hyperkalaemia, possibly with cardiac arrhythmias or cardiac arrest, especially in patients with impaired renal functions. Salicylates: Diuretic effects reduced by salicylates. Carbenoxolone: Ulcer healing effect antagonised by spironolactone. Food: Increased absorption of spironolactone. Lab tests: Interferes with radio-immuno assay for measuring digoxin, resulting in falsely elevated serum digoxin.

Servings: Hypertension: 50 to 100mg/day in divided doses. Oedema: 25 to 200mg/day in divided doses. Diagnosis of primary hyperaldosteronism: 400mg/day (short test) or up to four weeks (long test) Hirsutism: 25 to 200mg/day in divided doses. Premenstrual syndrome: 25mg four times on fourteenth day of menstrual cycle. Acne: 100mg/day.