- Duodenal and gastric bleeding
- Menstrual irregularities
- Testicular atrophy
- Hyper kalemia
- Altered levels of blood urea nitrogen
- Gastro intestinal disturbances
- Hypersensitivity to the drug
- Hyper kalaemia
- Acute and progressive renal insufficiency
- Renal impairment
- Hepatic impairment
- Fluid and electrolyte imbalance
Interaction: ACE Inhibitors: Enhanced hypotensive effect; significant hyperkalaemia may occur. Digitalis glycosides: Interaction is complex and may result in increased serum digoxin levels & subsequent digitalis toxicity. Cyclosporin: Increased risk of hyperkalaemia. Potassium Preparations: May result in hyperkalaemia, possibly with cardiac arrhythmias or cardiac arrest, especially in patients with impaired renal functions. Salicylates: Diuretic effects reduced by salicylates. Carbenoxolone: Ulcer healing effect antagonised by spironolactone. Food: Increased absorption of spironolactone. Lab tests: Interferes with radio-immuno assay for measuring digoxin, resulting in falsely elevated serum digoxin.
Servings: Hypertension: 50 to 100mg/day in divided doses. Oedema: 25 to 200mg/day in divided doses. Diagnosis of primary hyperaldosteronism: 400mg/day (short test) or up to four weeks (long test) Hirsutism: 25 to 200mg/day in divided doses. Premenstrual syndrome: 25mg four times on fourteenth day of menstrual cycle. Acne: 100mg/day.