Jonakayem Pharma Formulation (OPC) Pvt. Ltd.


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Sub Group Generic Formulary Brand Name Dosages Unit In treatment of Adverse Effects Contraiindication Special Precaution Interaction Servings

SILVER SULFADIAZINE Silvadene, Flamazine, Thermazene, 1 % W.W Tube Adjunctive prevention and treatment of infection in severe burns 1. Burning
2. Itching
3. Rashes
4. Systemic toxicity when applied on large surface area
5. Transient leucopenia (comes back to normal in 4 -5 days).

1. Hypersensitivity to Silver sulphadiazine and other Sulphonamide
2. Deep infections

1. Renal impairment
2. Hepatic impairment
3. G6PD deficiency
4. Withdraw the drug immediately if rashes appears

Cyclosporine: Decreased efficacy and increased nephrotoxicity with cotrimoxazole.
Methotrexate: Bone marrow depressant effect potentiated.
Phenytoin: Half-life prolonged.
Sulfonylureas: Increased hypoglycemic effect.
Thiazide diuretics: Increased risk of thrombocytopenic purpura in elderly.
Warfarin: Anticoagulant effect potentiated.
Pyrimethamine: Megaloblastic anaemia.
Oral contraceptives: Failure of oral contraceptives.
Lab test: Interferes with serum methotrexate assay by the competitive binding protein technique (CBPA).
Jaffe alkaline picrate reaction assay for creatinine: Overestimation of 10% of normal values.
Topical proteolytic enzymes: Silver may inactivate such enzymes.
Adult: Silver sulphadiazine 1 % w/ w cream and 1% w/ v solution is used. Apply as a film of about 2 -3 mm thick directly to the burn or on a sterile gauze dressing. If needed reapply after complete removal of previous applications with saline.