|Sub Group||Generic Formulations||Brand name||Dosages||Unit||In treatment of||Adverse Effects||Contraiindication||Special Precaution||Interaction||Servings|
|SILVER SULFADIAZINE||0.01||30 APPLICAPS||Bacterial or Fungal Conjunctivitis,Blepharitis,Keratitis and other infective Eye Condition||1. Burning
4. Systemic toxicity when applied on large surface area
5. Transient leucopenia (comes back to normal in 4 -5 days).
|1. Hypersensitivity to Silver sulphadiazine and other Sulphonamide
2. Deep infections
|1. Renal impairment
2. Hepatic impairment
3. G6PD deficiency
4. Withdraw the drug immediately if rashes appears
|Cyclosporine: Decreased efficacy and increased nephrotoxicity with cotrimoxazole.
Methotrexate: Bone marrow depressant effect potentiated.
Phenytoin: Half-life prolonged.
Sulfonylureas: Increased hypoglycemic effect.
Thiazide diuretics: Increased risk of thrombocytopenic purpura in elderly.
Warfarin: Anticoagulant effect potentiated.
Pyrimethamine: Megaloblastic anaemia.
Oral contraceptives: Failure of oral contraceptives.
Lab test: Interferes with serum methotrexate assay by the competitive binding protein technique (CBPA).
Jaffe alkaline picrate reaction assay for creatinine: Overestimation of 10% of normal values.
Topical proteolytic enzymes: Silver may inactivate such enzymes.
|Adult: Silver sulphadiazine 1 % w/ w cream and 1% w/ v solution is used. Apply as a film of about 2 -3 mm thick directly to the burn or on a sterile gauze dressing. If needed reapply after complete removal of previous applications with saline.|