Jonakayem Pharma Formulation (OPC) Pvt. Ltd.
PROPRANOLOL

PROPRANOLOL

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Product: PROPRANOLOL
Formulary: Generic Formulary
Category: Pain & Fever
Sub Group: ANTIMIGRAINE DRUGS
International Brand Name: Apo-Propranolol, pms Propranolol
Dosages: 40 MG/80 mg/60 mg
Unit of Packing: Tablets
In treatment of: Propphylaxis of Migrane

Adverse Effects: 

  • Congestive heart failure is precipitated or aggravated
  • Decreases coronary blood flow
  • Forgetfulness
  • Nightmares
  • Decreases exercise capacity
  • Decreases carbohydrate tolerance
  • Decrease insulin release
  • Increases free fatty acid levels and increase LDL to HDL ratio
  • Worsens chronic obstructive lung diseases
  • Gastrointestinal problems
  • Nausea
  • Sexual dysfunction
  • Cold extremities
  • Tiredness
  • Exacerbates prinzmetal`s angina
  • Bradycardia
  • Depression
  • Fever
  • Rash

Contraiindication: 

  • Hypersensitivity to the drug
  • Second or third degree heart block
  • Congestive heart failure
  • Cardiogenic shock
  • Bradycardia
  • Chronic obstructive pulmonary diseases
  • Hypoglycemia
  • Haemorrhage .

Special Precaution: 

  • Peripheral arterial diseases
  • Ischaemic heart disease
  • Congestive heart failure
  • Renal impairment
  • Hepatic impairment
  • Diabetes mellitus
  • The drug should be gradually withdraw with caution 
  • Non allergic bronchospastic diseases
  • Thyrotoxicosis 
  • Along with other antihypertensive drugs

Interaction: Quinidine: Orthostatic hypotension. Rifampicin, NSAIDs, Thyroid hormones, Smoking: Decrease antihypertensive action of propranolol. Corticosteroids: Antagonism of hypotensive effect. Sympathomimetics: Marked hypertension and bradycardia. Insulin: Hypoglycemic effects prolonged by propranalol and masking of symptoms of hypoglycemia in diabetes. Lidocaine: Increased levels of lidocaine may occur resulting in toxicity. Calcium channel blockers: Severe bradycardia especially in those with impaired LV function. Phenothiazines: Chlorpromazine increases plasma levels of propranolol. Reserpine: Additive effect resulting in vertigo, syncope or postural hypotension. Clonidine: May increase the postural hypotension. Severity of rebound hypertension caused by abrupt withdrawal of clonidine enhanced. Haloperidol: Severe hypotension. Prazosin: May increase first dose response (acute postural hypotension) of prazosin. Theophylline: Propranolol antagonises effect of theophylline.  ACE inhibitors: Enhanced hypotensive effect. Lab tests: May interfere with Glaucoma screening test due to reduction in intraocular pressure.

Servings: 40 to 240mg/day Hypertension: Starts with 80mg once daily or in 2 divided doses and gradually increases up to 320mg/day based on patient`s response in divided doses 12th hourly or 8th hourly. Maximum daily dose: 640mg. Sustained release formulations: 120 to 160mg/day. Once daily. Children: 1mg/kg/day gradually increases to 4mg/kg/day based on patient`s response in 4 divided doses Maximum dose: 5mg/kg/day. Arrhythmias & Anxiety: 30mg to 150mg/day in 3 to 5 divided doses. Children: 0.5 to 4mg/kg/day in 3 to 4 divided doses.