Jonakayem Pharma Formulation (OPC) Pvt. Ltd.
PROMETHAZINE

PROMETHAZINE

Send Inquiry

PROMETHAZINE

  • Product: PROMETHAZINE
  • Formulary: Generic Formulary
  • Category: Central Nervous System
  • Sub Group: ANTIEMETICS & ANTINAUSEANTS
  • International Brand Name: 
  • Dosages: 25 MG
  • Unit of Packing: Tablets
  • In treatment of: Prevention & treatment of Nause and vomiting associated w/ Labyrinthitis
Adverse Effects: 
  • Tardive dyskinesia
  • Extrapyramidal reactions
  • Drowsiness
  • Sedation
  • Dizzines
  • Hypotension
  • Dry mouth
  • Constipation
  • Blurred vision
  • Agranulocytosis
  • Photosensitivity
  • Insomnia
  • Weight gain
  • Cholestatic jaundice
Contraiindication: 
  • Hypersensitivity to Promethazine
  • Comatose
  • Blood dyscrasias
  • Patient taking antidepressants
  • Liver damage
Special Precaution: 
  • Renal impairment
  • Hepatic impairment
  • Cardiovascular disease
  • Pheochromocytoma
  • Hypocalcaemia
  • Epilepsy
  • Cholestatic jaundice
  • Patient exposed to extreme heat or cold or phosphorus insecticides
  • Ceribrovascular disorder
  • Patient on ECT
  • Reaction to Insulin
  • Prostatic hyperplasia
  • Glaucoma
  • Peptic ulcer
  • Slowly withdraw the drug with caution
Interaction: 

Alcohol: CNS depression, extrapyramidal reactions. Aluminium salts: Decrease efficacy. Antacids should be given 1 hour before or 2 hours after promethazine. Anticholinergics: Decrease efficacy and increase the anticholinergic side-effects of promethazine. Barbiturates: Decrease efficacy. Barbiturate anaesthetics: Increase frequency and severity of neuromuscular excitation and hypotension. Bromocriptine: Efficacy decreased by promethazine. Charcoal: Prevents absorption of promethazine. Lithium: Disorientation, unconsciousness and extrapyramidal symptoms. Meperidine: Excessive sedation and hypotension. TCAs: Serum concentration increased by promethazine. Propranolol: Increased plasma levels of both drugs. MAOIs: Additive orthostatic hypotensive effect. Lab tests: Pregnancy tests: False positive results. Plasma bound iodine (PBI): Increase in PBI occurs.

Servings: 

Adult: Motion sickness: 50 mg / day in 2 divided dose Allergy: 25 mg at bed time Nausea: 12.5 - 25 mg / day Sedation: 25 - 50 mg at bed time Children: Motion sickness: 12.5 - 25 mg / day Allergy: 6.25 - 12. 5 mg 3 times a day Sedation: 12.5 - 25 mg at bed time