Jonakayem Pharma Formulation (OPC) Pvt. Ltd.
OXYTOCIN

OXYTOCIN

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Product: OXYTOCIN
Formulary: Generic Formulary
Category: Genito Urinary System
Sub Group: DRUGS ACTING ON UTERUS
International Brand Name: Pitocin,Syntocinon
Dosages: 5U/0.5ML
Unit of Packing: Tablets
In treatment of: Ceasarian Section,3rd stage of Labour purperium,induction and augmentation of Labour; mgt of missed abortion,prevention of postpartum haemorrhage;treatment of postpartum haemorrhage

Contraiindication: 
  • Hypersensitivity to Oxytocin 
  • In unfavorable fetal positions (transverse lies, which are undeliverable without conversion prior to delivery) 
  • In obstetrical emergencies
  • In fetal distress where delivery is not imminent
  • Where adequate uterine activity fails to achieve satisfactory progress 
  • Where the uterus is already hyperactive or hypertonic 
  • Invasive cervical carcinoma
  • Active herpes genitalis
  • Total placenta previa, vasa previa
  • Prolapse of the cord
  • Cephalopelvic disproportion
Special Precaution: 
  • 1st and 2nd stages of labor
  • Uterine surgery
  • Cervical surgery 
  • Uterine sepsis
  • Grand multiparity
  • Overdistended uterus
  • Traumatic delivery 
  • Invasive cervical cancer
Adverse Effects: 
  • Hypersensitivity reaction 
  • Premature ventricular contractions 
  • Postpartum hemorrhage 
  • Subarachnoid hemorrhage 
  • Pelvic hematoma 
  • Nausea 
  • Vomiting 
  • Cardiac arrhythmia 
  • Hypertensive episodes 
  • Fatal afibrinogenemia
  • Rupture of the uterus
Interaction: Sympathomimetics: Pressor effect of sympathomimetics may be increased leading to postpartum hypertension. Prostaglandins: Risk of uterine repture & cervical lacerations. Ergotamine: Synergistic effect in control of post partum haemorrhage.

Servings: Intravenous or intramuscular Adult: 1. Induction of labour: Initial dose: 0.5- 1 milliunits /minute as IV infusion and if needed rate can be gradually increased by 1 - 2 milliunits/minute until sufficient response is obtained. 2. Augmentation of labour: Initial dose: 2milliunits/minute as intravenous infusion and then gradually increase the dose maximum up to 20milliunits/minute 3. Reduction of postpartum bleeding after expulsion of placenta: 20 - 40 milliunits/minute as intravenous infusion after delivery of placenta. 4. Induce abortion: 10 - 100 milliunits/minutes 5. Oxytocin challenge test to assess fetal distress in high risk pregnancies greater than 31 weeks` gestation: Initial dose: 0.5milliunits/minute followed by gradual increase in infusion rate every 15 minutes up to 20milliunits/minute. When 3 moderate uterine contractions occur in a 10 minute interval then stop the use of medicament.