Jonakayem Pharma Formulation (OPC) Pvt. Ltd.
MIFEPRISTONE

MIFEPRISTONE

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MIFETRISTONE

Sub Group Generic Formulations Brand Name Dosages Unit In treatment of Adverse Effects Contraindication Special Precaution Interaction Servings

MIFETRISTONE
200MG Tablets Cervical ripening,postcoital contraception,termination of pregnency (49 days or less duration),termination of pregnency up to 63 days,induction of labour following intrauterine foetal death, termination of pregnancy between 13-24 wk of gestation,softening and dilatation of cervix prior to surgical termination of pregnancy 1.Dizziness
2.Headache
3.Diarrhea
4.Nausea
5.Vomiting
6.Back pain
7.Feeling tired
8.Hot flashes
9.Abdominal pain
10.Anorexia
11.Vginal bleeding
12.Bad-smelling vaginal discharge
13.Fainting
14.Irregular heartbeat
15.Palpitations
16.Chest pain
17.Fever
18.Redness, blistering, peeling or loosening of the skin, including inside the mouth
19.Skin rash
20.Uterine infections
1.Hypersensitivity to Mifepristone
2.Ectopic pregnancy
3.Adrenal failure
4.Patient on long term corticosteroid therapy
5.Haemorrhagic disorder
6.Concurrent anticoagulant therapy
7.Inherited porphyria
8.Hepatic impairment
9.Renal impairment
1.Asthma
2.Chronic obstructive pulmonary diseases
3.Cardiovascular diseases
4.Smoking
5.Alcoholism
6.Should be taken prior to and during surgical abortion to prevent rhesus immunisation.
Ketoconazole, itraconazole, erythromycin, and grape fruit may inhibit mifepristone metabolism.
Rifampicin, dexamethasone, phenytoin, phenobarabital, carbamazepine induce mifepristone`s metabolism.
Adult:
1.Cervical ripening: 50 - 600mg to be taken 24 - 30 hour before surgery.
2.Postcoital contraception: 600mg as single dose within 3 days after intercourse.
3.Once a month contraceptive pill: 200mg as single dose on the second day after mid cycle.
4.Termination of pregnancy up to 49 days: 600 mg as single dose and after 2 days takes Misoprostol 400mcg as single dose.
5.Termination of pregnancy up to 63days: 600 mg as single dose and after 36 - 48 hours take Gemeprost vaginally.
6.Termination of pregnancy between 13 - 24 weeks of gestation: 600mg as single dose to be taken 36 - 48 hours before prostaglandin therapy
7.Induction of labour following intrauterine fetal death: 600mg / day for 2 days.
8.Softening and dilatation of cervix before surgical termination of pregnancy: 600 mg as single dose is given 36 - 48 hours before surgery.