|Sub Group||Generic Formulations||Brand Name||Dosages||Unit||In treatment of||Adverse Effects||Contraindication||Special Precaution||Interaction||Servings|
|MIFETRISTONE||200MG||Tablets||Cervical ripening,postcoital contraception,termination of pregnency (49 days or less duration),termination of pregnency up to 63 days,induction of labour following intrauterine foetal death, termination of pregnancy between 13-24 wk of gestation,softening and dilatation of cervix prior to surgical termination of pregnancy||1.Dizziness |
12.Bad-smelling vaginal discharge
18.Redness, blistering, peeling or loosening of the skin, including inside the mouth
|1.Hypersensitivity to Mifepristone |
4.Patient on long term corticosteroid therapy
6.Concurrent anticoagulant therapy
2.Chronic obstructive pulmonary diseases
6.Should be taken prior to and during surgical abortion to prevent rhesus immunisation.
|Ketoconazole, itraconazole, erythromycin, and grape fruit may inhibit mifepristone metabolism. |
Rifampicin, dexamethasone, phenytoin, phenobarabital, carbamazepine induce mifepristone`s metabolism.
1.Cervical ripening: 50 - 600mg to be taken 24 - 30 hour before surgery.
2.Postcoital contraception: 600mg as single dose within 3 days after intercourse.
3.Once a month contraceptive pill: 200mg as single dose on the second day after mid cycle.
4.Termination of pregnancy up to 49 days: 600 mg as single dose and after 2 days takes Misoprostol 400mcg as single dose.
5.Termination of pregnancy up to 63days: 600 mg as single dose and after 36 - 48 hours take Gemeprost vaginally.
6.Termination of pregnancy between 13 - 24 weeks of gestation: 600mg as single dose to be taken 36 - 48 hours before prostaglandin therapy
7.Induction of labour following intrauterine fetal death: 600mg / day for 2 days.
8.Softening and dilatation of cervix before surgical termination of pregnancy: 600 mg as single dose is given 36 - 48 hours before surgery.