Jonakayem Pharma Formulation (OPC) Pvt. Ltd.


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Formulary: Generic Formulary
Category: Infections & Infestations
International Brand Name: Flagyl
Dosages: 200 MG; 400 mg;
Unit of Packing: Tablets
In treatment of: Treatment of Trichomoniasis

Adverse Effects: 

  • Anorexia.
  • Metallic taste
  • Nausea
  • Vomiting
  • Diarrhoea
  • Headache
  • Looseness of stool.
  • Peripheral neuropathy &CNS effects.
  • Mutagenesis.
  • Radiosensitisation.
  • Transient leucopenia
  • Dry mouth
  • Abdominal distress
  • Dizziness
  • Vertigo
  • Thrombophlebitis at site of injection
  • Ototoxicity


  • Hypersensitivity to the drug
  • Blood dyscrasias
  • CNS disorders

Special Precaution: 

  • Renal impairment
  • Hepatic impairment
  • Alcoholic cirrhosis
  • Use cautiously along with other hepatotoxic drugs & In visual field changes

Interaction: Warfarin & other coumarin anticoagulants: Potentiates the anticoagulant effect resulting in increased prothrombin time. Alcohol: A disulfiram-like reaction. Abdominal cramps, nausea, vomiting, headache & flushing. Disulfiram: Acute psychotic reaction or confusional state. Phenobarbital & Phenytoin: Increased metabolism of metronidazole resulting in decreased efficacy. Lithium: Increased lithium levels and toxicity. Flurouracil: Increased toxicity of flurouracil. Lab tests: May interfere with chemical analysis for AST,SGOT, ALT, SGPT, LDH, triglycerides and hexokinase glucose. Zero values may occur.

Servings: Adult Amoebiasis:400 to 800 mg 8hourly for 5 to 10days depending up on the severity of infection In severe infections and liver abscess: 1gm as slow I.V. infusion followed by 0.5 gm twice daily till oral therapy is started Giardiasis:200mg 8hourly for 1week or 2gm/day for 3days or I.V.500mg thrice daily Trichomonas vaginitis: 400mg 8 hourly for a week or 2gm once daily for a week. Male partner should be concurrently treated with the drug Pseudo membranous enterocolitis:800 mg 8hourly Anaerobic bacterial infections after surgery, Brain abscess, & Endocarditis:400 to 800 mg 8hourly In severe cases: 15mg/kg I.V. infusion for 1hour followed by 7.5mg/kg 4 times daily till oral therapy is substituted Helicobacter pylori infections:400mg 8hourly along with amoxicillin/clarithromycin and a proton pump inhibitor Ulcerative gingivitis:200 to 800mg 8hourly Children Amoebiasis: 30 to 50mg/kg/day for 5to10 days. Giardiasis:10 to 15mg/kg/day thrice daily Children (below 12years): 7.5mg/kg I.V.