Jonakayem Pharma Formulation (OPC) Pvt. Ltd.


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Formulary: Generic Formulary
Category: Skin
Sub Group: ACNE
International Brand Name: Accutane,Amnesteem , Claravis, Clarus,Izotek , Oratane , Roaccutane , Sotret ,Isotrex, Isotrexin
Dosages: 10 MG/20 mg
Unit of Packing: Capsule
In treatment of: ACNE

Adverse Effects: 

  • Dryness of the skin nose, mouth and eyes
  • Epidermal fragility
  • Hyper pigmentation
  • Itching
  • Epistaxis (nosebleeds)
  • Chilitis
  • Blurred vision
  • Depression
  • Loss of appetite
  • Bloody diarrhea
  • Abdominal discomfort
  • Pain when swallowing
  • Heartburn
  • Yellowing of the skin or eyes or persistently dark urine
  • Severe headache
  • Dizziness
  • Seizures
  • Nausea
  • Vomiting
  • Joint or muscle pain or bone problems
  • Hearing problems
  • Depression

Contraiindication: Contraindicated to Isotretinoin

Special Precaution: 
  • Avoid exposure to sunlight and ultraviolet light
  • Avoid concurrent administration of Vitamin A
  • Avoid driving at night

Interaction: Alcohol: Etretinate formed in presence of alcohol. Antibacterials: Possible increased risk of benign intracranial hypertension with tetracyclines. Warfarin: Possible reduction in anticoagulant effect. Antiepileptics: Plasma concentration of carbamazepine may be reduced. Cytotoxic drugs: Plasma concentration of methotrexate may be increased. Oestrogens and progestogens: Contraceptive efficacy of low dose progestogens may be reduced but no effect on combined oral contracetives. Vitamins: Risk of hypervitaminosis with vitamin A.

Servings: Oral Adult: 0.5-1 mg/kg body weight/day in 2 divided doses with meals for 4-5 months