Jonakayem Pharma Formulation (OPC) Pvt. Ltd.
GLIPIZIDE

GLIPIZIDE

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Product: GLIPIZIDE
Formulary: Generic Formulary
Category: Diabetes
Sub Group: ORAL ANTIDIABETICS & RELATED DRUGS
Dosages: 5 MG
Unit of Packing: Tablets
In treatment of: treatment of type Diabetes Mellitus

Adverse Effects: 

  • Hypoglycemia
  • Nausea 
  • Vomiting 
  • Diarrhoea
  • Constipation 
  • Headache
  • Paresthesia 
  • Hypersensitivity reactions
  • Rashes 
  • Photosensitivity 
  • Purpura 
  • Transient leucopenia
  • Agranulocytosis

Contraiindication: 

  • Hypersensitivity to the drug
  • Diabetic ketoacidosis 
  • Diabetic coma 
  • Renal impairment 
  • Hepatic impairment 
  • Juvenile diabetes mellitus
  • Stress

Special Precaution: 

  • Malnourished and deliberate individuals
  • Strenous exercise and irregular meals may leads to hypoglycemia 
  • Hepatic diseases 
  • Renal diseases

Interaction: Hypoglycaemic effect of glipizide is enhanced by: Anticoagulants, Androgens, Chloramphenicol, Clofibrate, Fenfluramine, Fluconazole, Gemfibrozil, Histamine H2 antagonists, Magnesium Salts, Methyldopa, MAOIs, Phenylbutazone, Probenecid, Salicylates, Sulfinpyrazone, Sulfonamides, TCAs, & Urinary acidifiers. Hypoglycemic effect of glipizide inhibited by the following drugs: Beta-blockers, Cholestyramine, Diazoxide, Hydantoins, Rifampicin, Thiazide diuretics & Urinary alkalisers. Charcoal: Reduces the absorption of glipizide thus reducing its efficacy or toxicity. Digitalis glycosides: Coadministration results in increased digitalis serum levels.

Servings: Oral: Starts with 2.5 to 5mg daily; 30 minutes prior to breakfast. Adjust the dosage by increments of 2.5 to 5mg at weekly intervals up to 15mg/day as required.