Jonakayem Pharma Formulation (OPC) Pvt. Ltd.
GLIBENCLAMIDE

GLIBENCLAMIDE

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Product: GLIBENCLAMIDE
Formulary: Generic Formulary
Category: Diabetes
Sub Group: ORAL ANTIDIABETICS & RELATED DRUGS
International Brand Name: Glyburide,Diabeta, Glynase,micronose, Daonil, Semi-Daonil,Euglucon
Dosages: 2.5 MG/ 5 mg
Unit of Packing: Tablets
In treatment of: treatment of type Diabetes Mellitus

Adverse Effects: 

  • Hypoglycemia 
  • Nausea 
  • Vomiting 
  • Diarrhoea
  • Constipation 
  • Headache 
  • Presthesia 
  • Weight gain 
  • Hypersensitivity reactions 
  • Rashes 
  • Photosensitivity 
  • Purpura 
  • Transient leucopenia 
  • Agranulocytosis

Contraiindication: 

  • Hypersensitivity to the drug 
  • Diabetic ketoacidosis
  • Diabetic coma 
  • Renal impairment

Special Precaution: 

  • Hepatic impairment
  • Malnourished and deliberate individuals 
  • Strenous exercise and irregular meals may leads to hypoglycemia

Interaction: Hypoglycaemic effect of glibenclamide is enhanced by: Anticoagulants, Androgens, Chloramphenicol, Clofibrate, Fenfluramine, Fluconazole, Gemfibrozil, Histamine H2 antagonists, Magnesium Salts, Methyldopa, MAOIs, Phenylbutazone, Probenecid, Salicylates, Sulfinpyrazone, Sulfonamides, TCAs, & Urinary acidifiers. Hypoglycemic effect of glibenclamide inhibited by the following drugs: Beta-blockers, Cholestyramine, Diazoxide, Hydantoins, Rifampicin, Thiazide diuretics & Urinary alkalisers. Charcoal: Reduces the absorption of glibenclamide thus reducing its efficacy or toxicity. Digitalis glycosides: Co-administration results in increased digitalis serum levels.

Servings: Oral: Starts with 2.5mg once daily with breakfast. Adjust the dosage by increments of 2.5mg daily. Maximum dose: 15mg/day Maintenance dosage: 1.25 to 15mg once daily with breakfast or in divided doses; if gastrointestinal disturbances occur.