- Weight gain
- Hypersensitivity reactions
- Transient leucopenia
- Hypersensitivity to the drug
- Diabetic ketoacidosis
- Diabetic coma
- Renal impairment
- Hepatic impairment
- Malnourished and deliberate individuals
- Strenous exercise and irregular meals may leads to hypoglycemia
Interaction: Hypoglycaemic effect of glibenclamide is enhanced by: Anticoagulants, Androgens, Chloramphenicol, Clofibrate, Fenfluramine, Fluconazole, Gemfibrozil, Histamine H2 antagonists, Magnesium Salts, Methyldopa, MAOIs, Phenylbutazone, Probenecid, Salicylates, Sulfinpyrazone, Sulfonamides, TCAs, & Urinary acidifiers. Hypoglycemic effect of glibenclamide inhibited by the following drugs: Beta-blockers, Cholestyramine, Diazoxide, Hydantoins, Rifampicin, Thiazide diuretics & Urinary alkalisers. Charcoal: Reduces the absorption of glibenclamide thus reducing its efficacy or toxicity. Digitalis glycosides: Co-administration results in increased digitalis serum levels.
Servings: Oral: Starts with 2.5mg once daily with breakfast. Adjust the dosage by increments of 2.5mg daily. Maximum dose: 15mg/day Maintenance dosage: 1.25 to 15mg once daily with breakfast or in divided doses; if gastrointestinal disturbances occur.