Jonakayem Pharma Formulation (OPC) Pvt. Ltd.
DOXEPIN

DOXEPIN

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DOXEPIN 

Sub Group Generic Formulary Brand Name Dosages Unit In treatment of Adverse Effects Contraiindication Special Precaution Interaction Servings
ANTIPURITICS &SOOTHENING PREPARATION DOXEPIN Aponal, Adapine, Deptran, Sinquan and Sinequan 5% Tube- 15 gm
1. Drowsiness
2. Dizziness
3. Nausea
4. Vomiting
5. Blurred vision
6. Difficulty in micturition
7. Tachycardia
8. Hypotension
9. Arrhythmia
10. Dryness of mouth
11. Constipation
12. Confusion
13. Headache
14. Sedation
15. Urticaria
16. Rash
17. Pruritis
18. Jaundice
19. Anorexia
20. Impotence
21. Loss of libido
22. Galactorrhea
23.Gynecomastia
1.Hypersensitivity to Doxepin
2.Glaucoma
3.Epilepsy
4.Urinary retention.
1.Renal impairment
2.Hepatic impairment
3.Cardiac arrhythmia
4.Myocardial infarction
5.Tachycardia
6.Heart failure
7.Strokes
8.Alcoaholics
9.Patient on MAOI therapy (Discontinue the MAO inhibitor at least 2 weeks before Doxepin is started)
10.Slowly withdraw the drug with caution
11.Patient should be cautioned against driving vehicle, operating machine and activities requiring mental alertness and judgment


Anticholinergics: Enhanced effect of anticholinergics may occur.
Barabiturates: Serum level of imipramine decreased; additive respiratory depressant effect.
Clonidine: Hypertensive crisis.
Dicoumarol: Increase in anticoagulation effects.
Disulfiram: Acute organic brain syndrome.
Fluoxetine & Haloperidol: Potentiate action of Doxepin.
Levodopa: Its bioavailability is reduced, hypertensive episodes.
MAOIs, Furazolidone: Seizures, sweating, coma, hyperexcitablilty, hyperthermia, tachycardia, mydriasis, confusion, DIC. (Disseminated Intravascular Coagulation) and death.
Oral Contraceptives and Phenothiazines: Increase plasma levels of Doxepin.
Smoking: Increases metabolic bio-transformation.
Alcoahol: Sedative effect of alcoahol potentiated.
Adult: 25 mg 3 times daily; dose can be gradually increased until therapeutic response is obtained.
Maintenance dose: 100 - 150 mg / day
Maximum daily dose: 300 mg
Children: Not recommended