Jonakayem Pharma Formulation (OPC) Pvt. Ltd.
DESMOPRESSIN

DESMOPRESSIN

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Product: DESMOPRESSIN
Formulary: Generic Formulary
Category: Endocrine System
Sub Group: VASOPRESSIN ANALOGUES
International Brand Name: DDAVP, Stimate,Minirin
Dosages: 1MCG/ML
Unit of Packing: Vial/5 MD
In treatment of: Control of Cranial Diabetes insipidus;mgt of primary Nocturnal Enuresis

 Adverse Effects: 

  • Headache
  • Hyponatraemia
  • Fluid retention
  • Stomach pain
  • Nausea
  • Vomiting
  • Abdominal cramps
  • Epistaxis
  • Sore throat
  • Allergic manifestations
  • Urticaria
  • Anaphylaxis.

Contraiindication: 

  • Hypersensitivity to the drug
  • Type IIB Von Willebrand`s disease
  • Cardiac insufficiency
  • Conditions treated with diuretics

Special Precaution: 

  • Renal impairment
  • Hypertension 
  • Cardiovascular disease
  • Cystic fibrosis
  • Fluid and electrolyte imbalance.

Interaction: Analgesics: Effect of desmopressin potentiated by indomethacin.

Servings: Diagnosis of diabetes insipidus: 20mcg Adult: Intranasal: Diagnosis of diabetes insipidus: 20mcg Diabetes insipidus treatment: 10 to 40mcg in 1 to 3 divided doses. Use the lowest effective dose and separately adjust morning and evening doses for adequate diurnal rhythm of water turn over. Primary nocturnal enuresis: 20mcg as two to four metered sprays intranasally at bed time. Adjust the dosage based on patient`s response.Maximum dose: 40mcg/day. Kidney function test:40mcg after bladder emptying Oral: Diabetes insipidus: 100 to 200mcg thrice daily. Children: 5 to 20mcg at bed time. Primary nocturnal enuresis: children above 6 years:20mcg as two to four metered sprays intranasally at bed time. Adjust the dosage based on patient`s response.Maximum dose: 40mcg/day. Kidney function test: 20mcg after bladder emptying Children below 1 year old: 10mcg Reduce fluid intake to half for further two feeds Nocturia associated with multiple sclerosis: 10 to 20mcg at bed time.