Jonakayem Pharma Formulation (OPC) Pvt. Ltd.
DAUNORUBICIN

DAUNORUBICIN

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Sub Group Generic Formulary Brand Name Dosages Unit In treatment of Adverse Effects Contraiindication Special Precaution Interaction Servings

DAUNORUBICIN DaunoXome 20 mg Vial TREATMENT OF ACUTE LUKAEMIA 1. Nausea
2. Vomiting
3. Lowered resistance to infection
4. Bruising or unusual bleeding
5. Anemia
6. Weakness
7. Sore in mouth
8. Taste changes
9. Diarrhea
10. Loss of appetite
11. Visual changes
12. Black, tarry stools
13. Blood in urine or in stool
14. Cough or hoarseness
15. Fever
16. Chills
17. Lower back or side pain
18. Painful or difficult urination
19. Pinpoint red
20. Slurred speech
21. Swelling on leg or lower leg
22. Shortness of breath
23. Pulmonary fibrosis
24. Spot on skin
25. Alopecia
26. Seizures
27. Insomnia
28. Cardiomyopathy
29. Cardiac arrest
30. Pulmonary hypertension
31. Neutropenia
32. Injection site inflammation
33. Influenza like syndrome
34. Depression
1. Hypersensitivity to the drug
2. Cardiac diseases
3. Bone marrow suppression
4. Recent radiotherapy and chemotherapy
5. Recent immunizations
1. Hepatic impairment
2. Renal diseases
Immunisation with live vaccines not recommended as daunorubicin is immunosupressant.
Radiation: Enhanced radiation induced toxicity of myocardium, mucosa, skin & liver.
Heparin in solution, aluminium and dexamethasone: Incompatible with these drugs.
Intravenous-
Adults-
40mg/m2 over 60 minutes once every 2 weeks
30 to 60 mg/m2 once daily for 3 -6 consecutive days, starting on day 1.It is repeated every 3 to 4weeks.
Children-
25-45mg/m2/day for 3 to 4 weeks