Jonakayem Pharma Formulation (OPC) Pvt. Ltd.
DANAZOL

DANAZOL

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Product: DANAZOL
Formulary: Generic Formulary
Category: Genito Urinary System
Sub Group: DRUGS ACTING ON UTERUS
International Brand Name: Danocrine
Dosages: 50 MG/100mg/200mg
Unit of Packing: Capsule
In treatment of: Treatment of Endometriosis,preoperative thinning of the Endometrium

Adverse Effects: 

  • Amenorrhoea
  • Loss of libido in men
  • Hot flushes in women
  • Night sweats
  • Muscle cramps
  • Nausea
  • Gastrointestinal upset
  • Abnormal liver enzyme tests
  • Cholestatic jaundice
  • Androgenic effects in women
  • Acne
  • Hirsutism
  • Deepening of voice
  • Oedem
  • Weight gain
  • Muscle spasm
  • Headache
  • Sleep disorders.

Contraiindication: 

  • Abnormal genital bleeding of unknown etiology
  • Porphyria
  • Cardiac oedema
  • Renal impairment
  • Hepatic impairment
  • Pelvic infection
  • Undiagnosed uterine or ovarian masses
  • Jaundice on oral contraceptive therapy.

Special Precaution: 

  • Seizures
  • Migraine
  • Diabetes
  • Hypertension
  • Long term therapy
  • Monitor hepatic function tests

Interaction: Insulin: Increase in insulin requirement in diabetics due to insulin resistance. Warfarin: Potentiation of anti-coagulant effect. Oral contraceptives: Interfere with danazol action. Anti-epileptics: May require adjustment in their doses. Lab tests: Glucose Tolerance. Tests: Decreased glucose tolerance. Liver function Tests: Elevated values reported.

Servings: Oral: Mild endometriosis: Starts with 100 to 200mg 12th hourly up to 6months. Adjust the dosage based on patient`s response. Moderate to severe endometriosis: 400mg 12th hourly up to 6months. Fibrocystic breast disease, Gynaecomastia: 100 to 400mg/day as two divided doses for 2 to 6months. Menorrhagia: 200mg/day for 3 months. Hereditary angioedema: 200mg 12th hourly to 8th hourly until therapeutic effect is obtained. Then reduce the dosage to half at 1 to 3 month intervals.