Jonakayem Pharma Formulation (OPC) Pvt. Ltd.


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Sub Group Generic Formulary Brand Name Dosages Unit In treatment of Adverse Effects Contraiindication Special Precaution Interaction Servings

DACTINOMYCIN Cosmegen 500 mcg Vial Treatment of Wilm's Tumour,Ewing's Sarcoma and childhood Rhabdomyosarcoma 1. Nausea
2. Vomiting
3. Lowered resistance to infection
4. Bruising or unusual bleeding
5. Anemia
6. Weakness
7. Sore in mouth
8. Taste changes
9. Diarrhea
10. Loss of appetite
11. Visual changes
12. Black, tarry stools
13. Blood in urine or in stool
14. Cough or hoarseness
15. Fever
16. Chills
17. Lower back or side pain
18. Painful or difficult urination
19. Pinpoint red spot on skin
20. Slurred speech
21. Swelling on leg or lower leg
22. Shortness of breath
23. Bloody vomiting
24. Thinned or brittle hair
25. Mouth blistering
26. Thrombocytopenia
27. Leucopenia
28. Coma
29. Seizures
30. Pancytopenia
31. Agranulocytosis
32. Aplastic anemia
33. Myalgia
34. Hypocalcemia
35. Alopecia

1. Hypersensitivity to the drug
2. Chicken pox
3. Herpes zoster
1.GI toxicity and bone marrow suppression are results when it given with radiation
2.Discontinue the treatment if there is stomatitis, diarrhea or sever hematopoetic depression
May interfere with bioassay procedure for determination of antibacterial drug levels.

General dose-2.5mg/metre square in divided doses over 1week, repeated every 2 weeks OR 400-600mcg/metre square/day for 5 days, repeated every 3-6 weeks
General dose-15mcg/kg/day OR 400-600mcg/metre square/day for 5 days every 3-6 weeks