Jonakayem Pharma Formulation (OPC) Pvt. Ltd.
CLOMIFENE

CLOMIFENE

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Product: CLOMIFENE
Formulary: Generic Formulary
Category: Fertility & Antifertility Agents
International Brand Name: Treatment of antiovulatory infertility
Dosages: Clomid,Serophene, Milophene
Unit of Packing: 25 MG/50 mg/100 mg
In treatment of: Tablets

Adverse Effects: 

  • Cyts in ovaries
  • Multiple pregnancy
  • Hot flushes
  • Stomach upset
  • Nausea 
  • Vomiting
  • Vertigo
  • Breast tenderness
  • Dermatitis 
  • Rash
  • Urticaria
  • Increases the risk of ovarian tumor 
  • Spotting 
  • Alopecia

Contraiindication: 

  • Hepatic impairment
  • Undiagnosed genital bleeding 
  • Ovarian cysts not due to polycystic ovary disease 
  • Uncontrolled thyroid dysfunction 
  • Uncontrolled adrenal dysfunction 
  • Carcinoma of genital tract
  • Pituitary tumor.

Special Precaution: 

  • Therapy for infertility in females should be under direct supervision of a gynaecologist. 
  • Ovarian enlargement 
  • Long term therapy 
  • Along with alcohol
  • Along with antidepressants

Interaction: Gonadotropin Therapy: In combination, Gonadotropin therapy causes hyper-stimulation of ovary. Lab Tests: Levels of Thyroxine and Thyroxine-binding Globulin (TBG) increased. BSP (Bromsulphalein) Lab studies: greater than 5% retention of BSP reported in 10-20% of patients.

Servings: Oral: Anovulatory infertility: 50mg once daily for 5days starting from 5th day of menstrual cycle. (Starting from any time in women who have had no recent uterine bleeding). Dose may be increased to 100mg if ovulation does not occur. Repeat the 5 day course until conception occurs or until the completion of 3 courses. Male infertility: 25mg daily for 25 days followed by a rest period of 5days for 3 to 6 months.