Jonakayem Pharma Formulation (OPC) Pvt. Ltd.


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Formulary: Generic Formulary
Category: Genito Urinary System
Dosages: 12.5 MG/25 mg
Unit of Packing: Tablets
Adverse Effects: 
  • Dizziness
  • Nausea
  • Diarrhoea
  • Vomiting
  • Dry mouth
  • Weakness
  • Hypokalaemia
  • Hyponatraemia
  • Hyperuricaemia
  • Elevated levels of glucose, calcium, and lipids
  • Altered liver function tests
  • Altered kidney function tests
  • Gastro intestinal disturbances
  • Impotence
  • Visual impairment
  • Electrolyte imbalance
  • Jaundice
  • Ototoxicity


  • Hypersensitivity to the drug
  • Hypokalaemia
  • Hyperuricaemia
  • Renal impairment
  • Hepatic impairment
  • Anuria
  • Hyponatraemia
  • Hypercalcaemia
  • Addison`s disease
  • Chronic obstructive pulmonary diseases

Special Precaution: 

  • Gout
  • Hepatic diseases
  • Renal impairment
  • Fluid and electrolyte imbalance
  • Hyperlipidaemia
  • Severe heart failure
  • Cirrhosis
  • Diabetes mellitus
  • Ventricular extra systoles

Interaction: Cholestyramine & Colestipol : decrease absorption of chlorthalidone. Diazoxide : Additive action may cause hyperglycemia, hyperuricaemia and hypotension. Digitalis : Diuretic induced hypokalaemia may precipitate digitalis toxicity. Lithium : Chlorthalidone potentiates therapeutic and toxic effects by decreasing its renal excretion. Frusemide :Synergy leading to profound diuresis and greater than predicted electrolyte loss. Non-depolarizing muscle relaxants : Diuretic induced hypokalaemia enhances efficacy. Sulfonylureas : Efficacy decreased due to chlorthalidone induced glucose intolerance. Chlorpropamide : Hypokalemia. Propantheline : Bioavailability of chlorthalidone increased. Metoclopramide : Bioavailability of chlorthalidone decreased. NSAID

Servings: Adult: Hypertension: 25mg daily. Increased to 50mg if required; depending up on the patient`s response. Oedema: Starts with 50mg. Increased to 100 to 200mg on alternate days; if required. Maintenance dosage: 25 to 50mg daily or on alternate days. Children: Hypertension:2mg/kg/day; thrice a week.