- Hypersensitivity to the drug.
- Cardiovascular diseases.
- Kidney disease.
- Liver disease.
- Lung disease.
- Recent infection of the ovaries, fallopian tubes and uterus
- High blood pressure.
- Scarring of the womb.
- Cardiac arrest.
- Redness around injection site.
- Facial flushing.
- Increase in body temperature.
- Pulmonary oedema
Interaction: Oxytocin: Activity of oxytocin augmented and hence should be used sequentially and carefully monitored. Hyperosmolar Urea: Prior injection of urea enhances activity of carboprost. Mifepristone: Enhanced activity with fewer side effects.
Servings: Intramuscular- Adults- Termination of pregnancy: 250 mcg at intervals of 1.5-3.5 hours, depending on uterine response; may increase dose to 500 mcg if contractility is inadequate after several 250 mcg doses. Dose should not exceed 2 mg Control of hemorrhage: 250 mcg; additional doses may be administered between 15 and 90 minutes apart if needed. Dose should not exceed 2 mg Catheterization- Hemorrhagic Cystitis: 400-500mcg diluted in 50mL NS and instilled into the bladder; clamp catheter and allow solution to dwell for 60 minutes; repeat every 6 hours until response. Patient should change positions every 15 minutes while carboprost is in bladder