Jonakayem Pharma Formulation (OPC) Pvt. Ltd.
BETAMETHASONE

BETAMETHASONE

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Product: BETAMETHASONE
Formulary: Generic Formulary
Category: Endocrine System
Sub Group: CORTICOSTEROIDS
Dosages: 1MG/0.5 mg/0.5g/ml/4 mg
Unit of Packing: Tablets
In treatment of: Soft tissue inflammation

Adverse Effects: 

  • Susceptibility to infection
  • Peptic ulcer
  • Haemorrhage
  • Glycosuria
  • Hyperglycaemia
  • Osteoporosis
  • Atrophy of adrenal cortex(on prolonged therapy)
  • Suppression of adrenocorticotropic hormone
  • Cushing's syndrome 1
  • Inhibition of growth in children
  • Amenorrhoea
  • Behavioral disturbances
  • Thromboembolic disorders
  • Myopathy
  • Weakness
  • Lymphocytopenia
  • Muscle wasting
  • Gastrointestinal discomfort
  • Increased appetite
  • Delayed wound healing
  • Headache
  • Euphoria
  • Insomnia
  • Seizures
  • Heart failure
  • Arrhythmias
  • Posterior sub capsular cataract
  • Glaucoma
  • Hirsutism
  • Increased intracranial pressure. Topcal:
  • Burning
  • Irritation
  • Dryness
  • Erythema
  • Folliculitis
  • Striae
  • Skin atrophy
  • tching

Contraiindication: 

  • Hypersensitivity to the drug
  • Untreated infections
  • Systemic fungal infections Topical:
  • Hypersensitivity to Betamethasone and other corticosteroids
  • Untreated bacterial, virus or fungal infections
  • Acne vulgaris
  • Peri-oral dermatitis
  • Scabies
  • Leg ulcers
  • Tuberculosis of the skin
  • Varicose ulcers 
  • Skin lesions caused by infections with ring worm, fungi (e.g. Candida, Tinea) or bacteria (e.g. impetigo)
  • Discoid lupus Erythematosus

Special Precaution: 

  • Avoid sudden discontinuation of the drug
  • Use lower dosages as much as possible
  • Concurrent vaccination
  • Ocular herpes simplex
  • Primary glaucoma
  • Peptic ulcer
  • Psychosis
  • Tuberculosis
  • Epilepsy
  • Osteoporsis
  • Congestive heart failure
  • Renal impairment
  • Recent myocardial infarction
  • Heart failure
  • Diabetes mellitus
  • Hypothyroidism
  • Cirrhosis
  • Stress
  • Sepsis
  • Hypertension
  • Myasthenia gravis
  • Hepatic impairment
  • Non specific Ulcerative colitis
  • Diverticulitis
  • Recent intestinal anastomosis
  • Thromboembolic disorders
  • Avid contact of the topical dosage form with the eyes

Interaction: 

Barbiturates: Decrease efficacy of Betamethasone Carbamazepine, Primidone: Decreases efficacy. Oral contraceptives: Increase efficacy of Betamethasone. Oestrogens: Decreases efficacy of Betamethasone. Ketoconazole: Increases efficacy of Betamethasone. Rifampicin: Decreases efficacy. Betamethasone effects the actions of the following: Anticholinesterases: Efficacy antagonised in myasthenia gravis. Oral anticoagulants: Altered response. Cyclosporine: Increases efficacy leading to enhanced toxicity. Digitals glycosides: Increases toxicity associated with hypokalaemia. Isoniazid: Decreases serum levels. Salicylates: Decreases serum levels. Diuretics: Increases efficacy may cause increased hypokalaemia and increased hyperglycaemia. Non-depolarising muscle relaxants - Altered response. Somatrem: Growth promoting effect inhibited. Theophyllines: Altered response of either agent. IUCD: Contraceptive failure. Lab. Tests: a) Increases serum cholesterol levels. b) Increases urine glucose levels. c) Decreases Thyroid l 131 uptake; Decreases T3 serum levels. d) Decreases serum potassium.

Servings: Oral: Starts with 0.5 to 6mg/day. Reduces to minimum effective; maintenance dosage. Children: 1 to 6 years: 25 to 50% 7 to 12 years: 50 to 75% I.M. or I.V.: 4 to 20mg I.M. or as slow I.V. injection. Repeated if required; up to 4 times daily depending up on the severity of condition. Children: Administered by slow I.V. injection; <1year: 1mg 1 to 5 years: 2mg 6 to 12 years: 4mg Intra-articular or soft tissue injection: 0.5 to 9mg depending up on the severity of the condition. Topical: Betamethasone Valerate: Apply to the affected area as thin film 1 - 4 times daily depending upon the severity, skin and rate of absorption. Dermatoses of the scalp: (Betamethasone Valerate 0.12%): Small amount of foam is applied in to the scalp with gentle massage 2 times a day for up to 2 weeks. Betamethasone dipropionate: Apply to the affected area as thin film 1 -2times daily