Jonakayem Pharma Formulation (OPC) Pvt. Ltd.
AMILORIDE+ HYDRCHLOROTHIAZIDE

AMILORIDE+ HYDRCHLOROTHIAZIDE

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Product: AMILORIDE+ HYDRCHLOROTHIAZIDE
Formulary: Generic Formulary
Category: Genito Urinary System
Sub Group: DIURETICS
Dosages: 5MG +50 MG ; 2.5 mg+25 mg
Unit of Packing: Tablets
In treatment of: Induction of Diuresis

Adverse Effects: 

  • Dizziness
  • Blurred vision 
  • Confusion 
  • Tingling fingers 
  • Dry mouth 
  • Nausea 
  • Diarrhoea 
  • Constipation 
  • Vomiting 
  • Weakness 
  • Hypokalaemia 
  • Hyponatraemia 
  • Hyperuricaemia 
  • Elevated levels of glucose, calcium and lipids 
  • Gastro intestinal disturbances 
  • Polyuria
  • Electrolyte imbalance 
  • Jaundice 
  • Rashes 
  • Photosensitivity 
  • Fever 
  • Itching 
  • Myalgia 
  • Muscle cramps 
  • Arthralgia 
  • Blood dyscrasias 
  • Ototoxicity

Contraiindication: 

  • Hyper uricaemia 
  • Hyper calcaemia
  • Renal impairment 
  • Hepatic impairment 
  • Anuria 
  • Hypersensitivity to the drug 
  • Hyper sensitivity to sulfonamides 
  • Fluid and electrolyte imbalance

Special Precaution: 

  • Gout 
  • Diabetes mellitus 
  • Renal impairment 
  • Hepatic impairment 
  • Monitor and correct Fluid and electrolyte imbalance 
  • Hyper parathyroidism 
  • Cirrhosis

Interaction: Cholestyramine & Colestipol: decrease absorption of hydrochlorothiazide. Diazoxide: Additive action - may cause hyperglycemia, hyperuricaemia and hypotension. Digitalis: Diuretics induced hypokalaemia may precipitate digitalis toxicity. Lithium: Hydrochlorothiazide potentiates therapeutic and toxic effects by increasing its renal excretion. Frusemide: Synergy leading to profound diuresis and greater than predicted electrolyte loss. Non-depolarizing muscle relaxants: Diuretics induced hypokalaemia enhances efficacy. Sulfonylureas: Efficacy decreased due to hydrochlorothiazide induced glucose intolerance. Chlorpropamide: Hypokalaemia. Propantheline: Bioavailability of hydrochlorothiazide increased. Metoclopramide: Bioavailability of hydrochlorothiazide decreased. NSAIDs: Natriuretic effect of hydrochlorothiazide decreased.

Servings: Adults: Hypertension: 25mg once daily or in divided doses. Increased to 50mg if required; depending up on the patient`s response. Children: 1mg/kg single daily dose. Oedema: Adults: Starts with 25 to 50mg. Increased the dose until desired response is obtained. Maximum dose: 200mg/day Maintenance dosage: 25 to 100mg daily or on alternate days. Children: 1mg/kg single daily dose or 1 to 3mg/kg/day in two divided doses