Jonakayem Pharma Formulation (OPC) Pvt. Ltd.
ACETAZOLAMIDE

ACETAZOLAMIDE

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ACETAZOLAMIDE

Sub Group Generic Formulations Brand name Dosages Unit In treatment of Adverse Effects Contraiindication Special Precaution Interaction Servings
DRUGS FOR GLAUCOMA ACETAZOLAMIDE Diamox 250 MG 10 SR CAP Treatment of Open angle Glaucoma,Pre-opeartive management of angle closure Glaucoma 1.Numbness and tingling in fingers
2.Taste disturbances
3.Hypokalemia
4.Acidosis
5.Blurred vision
6.Headache
7.Drowsiness
8.Paresthesia
9. Fatigue
10.Abdominal discomfort
11.Nausea
12.Fever
13.Rashes
14.Allergic reactions
15.Bone marrow depression(rare)
16.Ototoxicity
1.Hypersensitivity to the drug
2.Hyponatremia
3.Hypokalemia
4.Renal impairment
5.Hepatic impairment
6.Adrenal insufficiency
7.Long term management of non congestive chronic angle closure glaucoma
8.Hyperchloremic acidosis.
1.Diabetes mellitus
2.Sickle cell anaemia
3.Gout
4.Hypesensitivity to Sulfonamides
5.Chronic obstructive pulmonary disorders
6.Emphysem
7.Respiratory acidosis
8.Along with other diuretics
Amphaetamine, Ephedraine, Flecainide, Pseudoaephedrine, Quinidine: Potentiates effect by decreasing their renal excretion.
Digitalis: Digitals toxicity since it induces hypokalemia
Primidone: May delay absorption.
Salicylates: Salicylate toxicity due to metabolic acidosis.
Corticosteroids: Hypokalemia.
Lithium: Efficacy diminished.
Sulfonamides: Aids penetration across Blood/CSF barrier.
Folic acid antagonists, Oral hypoglycaemic agents, Mercurial diuretics and Oral anticoagulants: May potentiate effect.
Lab Test: Urinary Proteins Determination - False positive results.
Glaucoma: 250mg 1 to 4 times daily
Epilepsy: Adults & Children: 8 to 30mg/kg/day in 2 to four divided doses.
Edema in heart failure: 250 to 375mg daily in the morning
Children: 5mg/kg/day orally or I.V. in the morning.
Acute mountain sickness: 250 mg 2 to 3 times daily or 500mg extended release formulation twice daily take 48 hours before ascent and continue until 48 hours after arrival at high altitude.