Jonakayem Pharma Formulation (OPC) Pvt. Ltd.
ACARBOSE

ACARBOSE

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Product: ACARBOSE
Formulary: Generic Formulary
Category: Diabetes
Sub Group: ORAL ANTIDIABETICS & RELATED DRUGS
International Brand Name: Glucobay,Precose, Prondose
Dosages: 25 MG/50mg
Unit of Packing: Tablets
In treatment of: treatment of type Diabetes Mellitus

Adverse Effects: 

  • Flatulence
  • Loose stools
  • Abdominal pain
  • Diarrhoea
  • Elevated serum transaminase levels (rare)

Contraiindication: 

  • Hypersensitivity to the drug
  • Diabetic ketoacidosis
  • Cirrhosis
  • Ulcerative colitis
  • Partial intestinal obstruction
  • Chronic intestinal diseases
  • Hepatic impairment
  • Severe renal impairment
  • History of abdominal surgery
  • Hernia.

Special Precaution: 

  • Mild to moderate renal impairment
  • Monitor hepatic function tests during therapy
  • Enhance hypoglycaemic effects of sulfonylureas. Give glucose in such situations.

Interaction: Sucrose: Abdominal discomfort or diarrhoea. Digestive enzymes (amylase, pancreatin) and intestinal adsorbents (charcoal): Reduce efficacy of acarbose. Sulphonylureas, biguanides: Acarbose increases their efficacy. Insulin: In IDDM, insulin requirement is reduced.

Servings: Oral: Start with 25mg thrice daily with the 1st bite of each main meal. Increased to 50mg thrice daily; at 4 to 8 week intervals based on 1st hour postprandial glucose levels and tolerance. Then increased to 100mg thrice daily if required. Maintenance dosage: 50mg to 100mg thrice daily; depending up on the patient`s weight. Maximum dose: 200mg thrice daily.